[Haematology] Cytology Atlas of Organ Biopsies and Exudates

Cytology Atlas of Organ Biopsies and Exudates, [Haematology] Cytology Atlas of Organ Biopsies and Exudates, Cytology of Organ Biopsies and Exudates, atlas in medical, tuyenlab.net, Reactive lymph node hyperplasia and lymphogranulomatosis, Boeck disease and tuberculosis, Non-Hodgkin lymphoma and tumor metastases, Cyst biopsy and bronchoalveolar lavage, Pleural effusion and ascites, Cerebrospinal fluid cytology

1. Reactive lymph node hyperplasia and lymphogranulomatosis.

Fig 1a. Lymph node cytology in severe reactive hyperplasia. Large blastic cells alongside small lymphocytes (if it fails to regress, histological analysis is required).

Fig 1b. Hodgkin disease: a giant mononuclear cell with a large nucleolus (arrow) and wide cytoplasmic layer (Hodgkin cell), surrounded by small and medium-sized lymphocytes.

Fig 1c. Hodgkin disease: giant binuclear cell (Reed–Sternberg giant cell).

2. Boeck disease and tuberculosis.

Fig 2a. Lymph node cytology in Boeck disease: a special form of reactive cell pattern with (often predominating) islands and trains of epithelioid cells (arrow), which have ovoid nuclei with delicate chromatin structure and a wide, smoke-gray layer of cytoplasm.

Fig 2b. Lymph node cytology in tuberculous lymphadenitis: in addition to lymphocytes and a few epithelial cells (1), enormous syncytes of epithelioid cell nuclei within one cytoplasm (arrow) may be encountered: the Langhans giant cell.

3. Non-Hodgkin lymphoma and tumor metastases

Fig 3a. Lymph node cytology showing small cells with relatively wide cytoplasm (arrow 1) in addition to lymphocytes. There are scattered blasts with wide cytoplasm (arrow 2): lymphoplasmacytic immunocytoma.

Fig 3b. Lymph node cytology showing exclusively large blastoid cells with a large central nucleolus (arrow). This usually indicates large-cell non- Hodgkin lymphoma (in this case immunoblastic).

Fig 3c. Metastatic disease from: uterine carcinoma

Fig 3d. Metastatic disease from: small-cell bronchial carcinoma

Fig 3e. Metastatic disease from: leiomyosarcoma.

4. Cyst biopsy and bronchoalveolar lavage.

Fig 4a.  Cytology of a lateral neck cyst: no lymphatic tissue, but epithelial cells from the floor of the mouth.

Fig 4b. Normal ciliated epithelial cells with typical cytoplasmic processes. 

Fig 4c. Tumor cell conglomeration in small-cell bronchial carcinoma: conglomeration is typical of tumor cells.

Fig 4d. Bronchoalveolar lavage in purulent bronchitis: a macrophage with pigment inclusion (arrow) is surrounded by segmented neutrophilic granulocytes.

5. Pleural effusion and ascites

Fig 5a.  Pleural cytology, nonspecific exudate: dormant mesothelial cell (or serosal cover cell) (1), phagocytic macrophage with vacuoles (2), and monocytes (3), in addition to segmented neutrophilic granulocytes (4).

Fig 5b. Cell composition in a pleural aspirate (prepared using a cytocentrifuge): variable cells, whose similarity to cells in acute leukemia should be established by cytochemistry and marker analysis: lymphoblastic lymphoma.

Fig 5c. Ascites with tumor cell conglomerate, surrounded with granulocytes and monocytes, in this case of ovarian carcinoma.

Fig 5d. Ascites cytology with an island of tumor cells. This kind of conglomeration
is typical of tumor cells.

6. Cerebrospinal fluid cytology.

Fig 6a. Cerebrospinal fluid cytology in bacterial meningitis: granulocytes with phagocytosed diplococci (in this case, pneumococci, arrow).

Fig 6b. Cerebrospinal fluid cytology in viral meningitis: variable lymphoid cells.

Fig 6c. Cerebrospinal fluid cytology in non-Hodgkin lymphoma: here, mantle cell lymphoma.

Fig 6d. Cerebrospinal fluid cytology after subarachnoid hemorrhage: macrophages with phagocytosed erythrocytes.

Fig 6e. Cerebrospinal fluid cytology in meningeal involvement in malignancy: the origin of the cells cannot be deduced with certainty from the spinal fluid cytology alone: breast cancer

Fig 6f. Cerebrospinal fluid cytology in meningeal involvement in malignancy: the origin of the cells cannot be deduced with certainty from the spinal fluid cytology alone: bronchial carcinoma

Fig 6g. Cerebrospinal fluid cytology in meningeal involvement in malignancy: the origin of the cells cannot be deduced with certainty from the spinal fluid cytology alone: medulloblastoma

Fig 6h. Cerebrospinal fluid cytology in meningeal involvement in malignancy: the origin of the cells cannot be deduced with certainty from the spinal fluid cytology alone: acute leukemia

This is only a part of the book : Color Atlas of Hematology: Practical Microscopic and Clinical Diagnosis (Clinical Sciences) 2nd of authors: Harald Theml, M.D; Heinz Diem, M.D and Torsten Haferlach, M.D. If you want to view the full content of the book and support author. Please buy it here: https://goo.gl/sxasqM