[Pathology] Atlas of Reactive, Developmental, Inflammatory, and Tumorlike Conditions (part 5)

[Pathology] Atlas of Reactive, Developmental, Inflammatory, and Tumorlike Conditions (part 5)

Continued of part 4: [Pathology] Atlas of Reactive, Developmental, Inflammatory, and Tumorlike Conditions (part 4)

Fig. 1.40 This mediastinal ectopic parathyroid adenoma shows a

homogeneous, red-brown cut surface

Fig. 1.41 The histologic appearance of an ectopic parathyroid adenoma in the 

mediastinum shows typical clear cell acinar architecture.

Notice remnants of involuting thymus in the vicinity (bottom left)

Fig. 1.42 At higher magnification, an ectopic mediastinal parathyroid

adenoma shows sheets of clear cells (top right) and cord-like, elongated

strands of involuted thymic tissue (bottom left) composed of small 

spindle cells admixed with scant lymphocytes

Fig. 1.43 The gross appearance of the cut surface of a mediastinal thymolipoma 

(lipomatous hamartoma) shows a well-circumscribed tumor

mass surrounded by a thin capsule and primarily composed of yellow,

lobulated fatty tissue

Fig. 1.44 The histologic appearance of a thymolipoma shows small

residual islands of involuted thymic epithelium, with normal preservation

 of corticomedullary architecture surrounded by abundant mature

adipose tissue

Fig. 1.45 A histologic variation of thymolipoma is characterized by

atrophic strands of involuting thymic epithelium embedded in abundant

hyalinized stroma and admixed with lobules of mature adipose tissue.

Such cases have been designated as “thymofibrolipoma”

Fig. 1.46 At higher magnification, thymofibrolipoma shows slender,

elongated strands of thymic epithelial cells composed of small oval to

spindle cells with scant cytoplasm and dispersed nuclear chromatin,

surrounded by abundant paucicellular, fibrous connective tissue

Fig. 1.47 Castleman’s disease, hyaline-vascular type, presenting as a

mediastinal mass in a 54-year-old woman. The cut surface shows a tanwhite,

 homogeneous appearance with slight lobularity and a rubbery consistency

Fig. 1.48 Castleman’s disease of the mediastinum, hyaline-vascular

type, shows striking lymphoid hyperplasia, with some of the follicles

showing expanded mantle zones containing more than one germinal

center within each follicle  

Fig. 1.49 Another area of mediastinal lymph node involved with

Castleman’s disease shows scattered small, dysplastic follicles with

burned-out germinal centers admixed with a larger follicle (center)

showing prominent vessels within the germinal center  

Continue part 6: 
[Pathology] Atlas of Reactive, Developmental, Inflammatory, and Tumorlike Conditions (part 6)

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